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Increased leucocyte apoptosis in transfused β-thalassaemia patients

Walter, PB; Porter, J; Evans, P; Kwiatkowski, JL; Neufeld, EJ; Coates, T; Giardina, PJ; ... Harmatz, P; + view all (2013) Increased leucocyte apoptosis in transfused β-thalassaemia patients. British Journal of Haematology , 160 (3) pp. 399-403. 10.1111/bjh.12076.

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Abstract

This exploratory study assessed apoptosis in peripheral blood leucocytes (PBL) from β-thalassaemia patients receiving chronic transfusions and chelation therapy (deferasirox or deferoxamine) at baseline, 1, 6, and 12 months. At baseline, thalassaemic PBLs presented 50% greater levels of Bax (BAX), 75% higher caspase-3/7, 48% higher caspase-8 and 88% higher caspase-9 activities and 428% more nucleosomal DNA fragmentation than control subjects. Only neutrophils correlated significantly with apoptotic markers. Previously, we showed that over the treatment year, hepatic iron declined; we now show that the ratio of Bax/Bcl-2 (BCL2), (-27·3%/year), and caspase-9 activity (-13·3%/year) declined in both treatment groups, suggesting that chelation decreases body iron and indicators of PBL apoptosis. © 2012 Blackwell Publishing Ltd.

Type: Article
Title: Increased leucocyte apoptosis in transfused β-thalassaemia patients
DOI: 10.1111/bjh.12076
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1543520
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