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Evaluation of the biocompatibility of nano-sized carbonate-substituted hydroxyapatite after hydrothermal treatment

Huang, J; Brooks, RA; Best, SM; Bonfield, W; (2003) Evaluation of the biocompatibility of nano-sized carbonate-substituted hydroxyapatite after hydrothermal treatment. BIOCERAMICS 15 , 240-2 485 - 488.

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Abstract

A hydrothermal treatment has been applied in this study to control the crystallinity and morphology of nanometre scale carbonate-substituted hydroxyapatite (C-HA) crystallites. Transmission electron microscopy showed that the morphology of C-HA was changed from acicular to rod-like by the treatment, while, selected area diffraction patterns changed from the ringed pattern of an amorphous material to the spotted pattern of a polycrystalline material. The increase in the crystallinity of C-HA was also confirmed by X-ray diffraction and infrared spectroscopy. Biocompatibility testing showed that there was some evidence of LDH release from primary human monocytes/macrophages when in contact with high concentrations of C-HA crystallites, but there was no significant release of inflammatory cytokine TNF-alpha. Moreover, the nano-sized C-HA crystallites were not cytotoxic to human osteoblast-like MG63 cells and normal actin cytoskeletal organization was observed. These results indicate the biocompatibility of these nano-sized C-HA crystallites, which may offer the potential to formulate composites for biomedical applications.

Type: Article
Title: Evaluation of the biocompatibility of nano-sized carbonate-substituted hydroxyapatite after hydrothermal treatment
Location: UNIV TECHNOL, SYDNEY, AUSTRALIA
Keywords: nanosize, carbonate-substituted hydroxyapatite, hydrothermal treatment, biocompatibility, LDH, TNF-alpha, confocal microscopy
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/154309
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