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Adult pneumococcal vaccination: advances, impact, and unmet needs

José, RJ; Brown, JS; (2017) Adult pneumococcal vaccination: advances, impact, and unmet needs. Current Opinion in Pulmonary Medicine , 23 (3) pp. 225-230. 10.1097/MCP.0000000000000369. Green open access

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Abstract

PURPOSE OF REVIEW: Preventing pneumonia in the elderly and study participants individuals with comorbidities is an unmet clinical need. Streptococcus pneumoniae is the commonest bacterial cause of pneumonia, and we summarize recent findings regarding current S. pneumoniae vaccines, and debate their efficacy and cost-effectiveness in risk groups. We also discuss potential future vaccine strategies such as protein antigen vaccines. RECENT FINDINGS: Current vaccination with pneumococcal polysaccharide vaccine does not prevent S. pneumoniae pneumonia. Vaccination with pneumococcal conjugated vaccine (PCV) prevents nasopharyngeal colonization, but although PCV13 has recently been shown to prevent S. pneumoniae pneumonia in adults, its overall efficacy was relatively low. The results of cost-effectiveness studies of PCV vaccination in adults are variable with some showing this is a cost-effective strategy, whereas others have not. The lack of cost-effectiveness is predominantly because of the current cost of the PCV vaccine and the existing herd immunity effect from childhood PCV vaccination on vaccine serotypes. SUMMARY: S. pneumoniae pneumonia is a vaccine-preventable disease but remains a common cause of morbidity and mortality. Advances in vaccination using approaches that induce serotypes-independent immunity and are immunogenic in high-risk groups are required to reduce the burden of disease because of S. pneumoniae.

Type: Article
Title: Adult pneumococcal vaccination: advances, impact, and unmet needs
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/MCP.0000000000000369
Publisher version: http://dx.doi.org/10.1097/MCP.0000000000000369
Language: English
Additional information: Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. This is a non-final version of an article published in final form in José, RJ; Brown, JS; (2017) Adult pneumococcal vaccination: advances, impact, and unmet needs. Current Opinion in Pulmonary Medicine 10.1097/MCP.0000000000000369
Keywords: Conjugated vaccine, immunosenescence, pneumonia, Streptococcus pneumoniae, unconjugated vaccine
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1542829
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