Barrett, JC; Clayton, DG; Concannon, P; Akolkar, B; Cooper, JD; Erlich, HA; ... Type 1 Diabet Genetics Consortium,; + view all Barrett, JC; Clayton, DG; Concannon, P; Akolkar, B; Cooper, JD; Erlich, HA; Julier, C; Morahan, G; Nerup, J; Nierras, C; Plagnol, V; Pociot, F; Schuilenburg, H; Smyth, DJ; Stevens, H; Todd, JA; Walker, NM; Rich, SS; Type 1 Diabet Genetics Consortium,; - view fewer (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. NAT GENET , 41 (6) 703 - 707. 10.1038/ng.381.
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Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 x 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
|Title:||Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes|
|Keywords:||SUSCEPTIBILITY LOCUS, CHROMOSOME, DISEASE, REGION, GENES, HLA, VARIANTS, MELLITUS, PTPN22, TESTS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Genetics, Evolution and Environment > UCL Genetics Institute|
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