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The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres

Craig, DQM; Yang, F; Chen, D; Guo, Z-F; Zhang, Y-M; Liu, Y; Askin, S; (2017) The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres. International Journal of Pharmaceutics , 522 (1-2) pp. 34-49. 10.1016/j.ijpharm.2017.02.056. Green open access

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Abstract

Poly (d,l-lactic-co-glycolic) acid (PLGA) based microspheres have been extensively used as controlled drug release systems. However, the burst effect has been a persistent issue associated with such systems, especially for those prepared by the double emulsion technique. An effective approach to preventing the burst effect and achieving a more ideal drug release profile is to improve the drug distribution within the polymeric matrix. Therefore, it is of great importance to establish a rapid and robust tool for screening and optimizing the drug distribution during pre-formulation. Transition Temperature Microscopy (TTM), a novel nano-thermal and imaging technique, is an extension of nano-thermal analysis (nano-TA) whereby a transition temperature is detected at a localized region of a sample and then designated a color based on a particular temperature/color palette, finally resulting in a coded map based on transition temperatures detected by carrying out a series of nanoTA measurements across the surface of the sample. In this study, we investigate the feasibility of applying the aforementioned technique combined with other thermal, imaging and structural techniques for monitoring the drug microstructure and spatial distribution within bovine serum albumin (BSA) loaded and nimodipine loaded PLGA microspheres, with a view to better predicting the in vitro drug release performance.

Type: Article
Title: The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2017.02.056
Publisher version: http://dx.doi.org/10.1016/j.ijpharm.2017.02.056
Language: English
Additional information: Copyright © 2017. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Transition temperature microscopy; Microsphere; Bovine serum albumin; Nimodipine; Poly (d,l-lactic-co-glycolic) acid; Controlled drug release
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: http://discovery.ucl.ac.uk/id/eprint/1542221
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