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Measuring high-sensitivity cardiac troponin T blood concentration in population surveys

Lazzarino, AI; Mindell, JS; (2017) Measuring high-sensitivity cardiac troponin T blood concentration in population surveys. PLoS One , 12 (1) , Article e0171242. 10.1371/journal.pone.0171242. Green open access

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Abstract

INTRODUCTION: The blood test for high-sensitivity cardiac troponin T (HS-CTnT) has been proposed as a marker of cardiovascular risk in the general population, as it is associated with subsequent incidence of cardiovascular events and mortality. We aimed at evaluating the feasibility of HS-CTnT testing within large nationally-representative population surveys in which blood samples are collected during household visits, shipped using the standard civil postal service, and then frozen for subsequent analyses. METHODS: The Health Survey for England (HSE) consists of a series of annual surveys beginning in 1991. It is designed to provide regular information on various aspects of the nation's health and risk factors. We measured HS-CTnT in the blood of 200 people from the HSE 2016 wave, then froze and stored their blood samples at -40°C for 5-10 weeks, and then thawed and retested them to appreciate the extent of within-person agreement or test-retest reliability of the two measurements. RESULTS: The Cronbach's Alpha (Scale Reliability Coefficient) and the Interclass Correlation Coefficient (two-way mixed-effects model for consistency of agreement at individual level) were 0.97 (95%CI = 0.96-0.99) and 0.95 (95%CI = 0.94-0.96) respectively. The time delay from blood withdrawal to analysis and storage (1-4 days) did not affect the results, nor did the freezing time before the retest (5-10 weeks). CONCLUSION: The measurement of HS-CTnT plasma concentration within large nationally-representative surveys such as the Health Survey for England is feasible.

Type: Article
Title: Measuring high-sensitivity cardiac troponin T blood concentration in population surveys
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0171242
Publisher version: http://dx.doi.org/10.1371/journal.pone.0171242
Language: English
Additional information: Copyright © 2017 Lazzarino, Mindell. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/1541080
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