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Hexamidine salts - applications in skin health and personal care products.

Parisi, N; Matts, PJ; Lever, R; Hadgraft, J; Lane, ME; (2017) Hexamidine salts - applications in skin health and personal care products. International Journal of Cosmetic Science , 39 (4) pp. 361-365. 10.1111/ics.12392.

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Abstract

Hexamidine (HEX) has been used as a preservative in topical preparations since the 1950s. A number of studies also indicate that the molecule plays a beneficial role in skin homeostasis. In this review we describe the physicochemical properties of hexamidine diisethionate (HEX D) and the corresponding hydrochloride salt (HEX H). The biocidal and protease inhibition properties of HEX are outlined as well as the effects of HEX on lipid processing enzymes, corneocyte maturity, stratum corneum thickness and Trans epidermal water loss (TEWL). Skin permeation properties of HEX D and HEX H are summarised and formulation approaches for effective dermal targeting of HEX are discussed. This article is protected by copyright. All rights reserved.

Type: Article
Title: Hexamidine salts - applications in skin health and personal care products.
Location: England
DOI: 10.1111/ics.12392
Publisher version: http://dx.doi.org/10.1111/ics.12392
Language: English
Additional information: This is the peer reviewed version of the following article: Parisi, N., Matts, P. J., Lever, R., Hadgraft, J. and Lane, M. E. (2017), Hexamidine salts – applications in skin health and personal care products. Int J Cosmet Sci. Accepted Author Manuscript. doi:10.1111/ics.12392 , which has been published in final form at http://dx.doi.org/10.1111/ics.12392. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Hexamidine, biocide, formulation, protease inhibitor, salt, skin
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1540352
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