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Formation of Highly Metastable β Glycine by Confinement in Inkjet Printed Droplets

Buanz, ABM; Gaisford, S; (2017) Formation of Highly Metastable β Glycine by Confinement in Inkjet Printed Droplets. Crystal Growth & Design , 17 (3) pp. 1245-1250. 10.1021/acs.cgd.6b01633. Green open access

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Abstract

Inkjet printing was used to deposit picoliter droplets of aqueous glycine solution onto glass or aluminum substrates and it was found that the volume constraint on crystal growth resulted in formation of the highly metastable β form. When the droplet volume increased to 0.1 μL or greater, a mixture of the α and β forms was seen in a coffee-ring formation. When the droplet volume increased to 10 μL, needle-like β crystals formed in the bulk of the ring and bipyramidal α crystals on the outer edge at the air–water interface. The β form was stable under ambient conditions for at least 6 weeks. The observations suggest that glycine nucleates to, and remains stable as, the β form when constrained in small volumes, because on the nanometer scale the β form is thermodynamically stable. As the droplet volume increases, and constraint on crystal growth is reduced, the α form becomes thermodynamically stable, and so phase transformation occurs, probably facilitated by a solvent-mediated mechanism. Inkjet printing picoliter droplets may offer a new route to isolation of metastable polymorphs.

Type: Article
Title: Formation of Highly Metastable β Glycine by Confinement in Inkjet Printed Droplets
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.cgd.6b01633
Publisher version: http://dx.doi.org/10.1021/acs.cgd.6b01633
Language: English
Additional information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: http://dx.doi.org/10.1021/acs.cgd.6b01633.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: http://discovery.ucl.ac.uk/id/eprint/1540142
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