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Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process

Steinlin, M; O'callaghan, F; Mackay, MT; (2017) Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process. Developmental Medicine and Child Neurology , 59 (7) pp. 713-718. 10.1111/dmcn.13393. Green open access

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Abstract

AIM: There is a paucity of data from randomized controlled treatment trials in childhood arterial ischaemic stroke. Our objectives were to identify and plan a trial through use of a Delphi consensus process. METHOD: The Delphi panel consisted of Australian, New Zealand, and European paediatric neurologists with interests in childhood stroke. Four rounds were conducted using a REDCap (Research Electronic Data Capture) Web-based application: the first consisted of open-ended questions; the second evaluated agreement for the most important trial; the third and fourth reached consensus on design. RESULTS: Forty-seven out of 66 neurologists answered the first round. Eight areas of research for important and feasible trials were identified. In the second round, 43 paediatric neurologists ranked the three highest rated trials: (1) aspirin versus aspirin plus steroids in focal arteriopathy (n=31); (2) heparin versus aspirin (n=6); and (3) heparin versus aspirin versus modern anticoagulation (n=6). The third and fourth surveys reached consensus among 43 out of 44 respondents on design of the highest ranked trial, and allowed agreement on inclusion/exclusion criteria, clinical/neuroimaging data, and treatment protocols. CONCLUSION: The Delphi consensus process is an efficient method of identifying and planning paediatric stroke trials. An international, multicentre trial is now in preparation.

Type: Article
Title: Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/dmcn.13393
Publisher version: http://dx.doi.org/10.1111/dmcn.13393
Language: English
Additional information: © 2017 Mac Keith Press. This is the peer reviewed version of the following article: Steinlin, M; O'callaghan, F; Mackay, MT; (2017) Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process. Developmental Medicine and Child Neurology, which has been published in final form at http://dx.doi.org/10.1111/dmcn.13393. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1539834
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