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Diet, nutrition and physical activity in endometrial cancer survivors

Koutoukidis, D; (2017) Diet, nutrition and physical activity in endometrial cancer survivors. Doctoral thesis , UCL (University College London). Green open access

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Abstract

Endometrial cancer survivors comprise a high-risk group for obesity-related comorbidities. Healthy eating and physical activity can lead to better health and well-being, but this population may experience difficulties adopting healthy lifestyle practices. Personalised behaviour change programmes that are feasible, acceptable, and cost-effective are needed. Using various methodologies, this doctoral research aimed to develop and pilot a healthy eating and physical activity program. Through a systematic literature review and meta-analysis, study 1 demonstrated preliminary evidence that obesity is positively associated with overall mortality. Expanding the review, study 2 indicated that a healthy lifestyle is positively associated with health-related quality of life. Study 3 primarily piloted the instruments and procedures for the trial. Study 4, using qualitative methodology, suggested that interventions should incorporate recommendations on managing late-treatment effects, and behaviour change techniques for cognitive, practical, and social barriers to healthy lifestyle changes. Based on this feedback, an evidence-based weight management programme was adapted using the intervention mapping systematic framework in study 5. Subsequently, the programme was piloted in a phase II, individually randomized, parallel, controlled, two-site, pilot clinical trial in study 6. Adult endometrial cancer survivors (n = 60) who had been diagnosed with endometrial cancer within the previous 3 years and were not on active treatment were assigned in a 1:1 ratio through minimisation to either the 8-week, group-based, behaviour-change programme with weekly 90-min sessions about healthy eating and physical activity or usual care. Follow-up assessments were conducted at 8 and 24 weeks from the baseline assessment. The intervention, which focused on self-monitoring, goal setting, and self-incentives, was feasible in terms of recruitment, adherence, and retention. It also showed promising effectiveness. The study results will inform the development of a randomised controlled trial to test if the programme can improve the health and quality of life of this population.

Type: Thesis (Doctoral)
Title: Diet, nutrition and physical activity in endometrial cancer survivors
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Keywords: Nutrition, dietetics, endometrial cancer, cancer survivorship, behaviour change, healthy eating, physical activity, randomised controlled trial, intervention mapping
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Women's Cancer
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: http://discovery.ucl.ac.uk/id/eprint/1539075
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