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Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?

Lawrence, AD; Evans, AH; Lees, AJ; (2003) Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry? LANCET NEUROL , 2 (10) 595 - 604.

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Abstract

Dopamine replacement therapy (DIRT) is the most effective treatment for Parkinson's disease (PD); it provides substantial benefit for most patients, extends independence, and increases survival. A few patients with PD, however, take increasing quantities of medication far beyond those required to treat their motor disabilities. These patients demand rapid drug escalation and continue to request more DRT despite the emergence of increasingly severe drug-induced motor complications and harmful behavioural consequences. In this article we detail the features of compulsive DRT-seeking and intake in PD, in relation to theories of compulsive drug use.

Type: Article
Title: Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?
Keywords: LEVODOPA-INDUCED DYSKINESIAS, CONDITIONED PLACE PREFERENCE, NUCLEUS-ACCUMBENS DOPAMINE, DRUG-ABUSE, HOMEOSTATIC DYSREGULATION, INCENTIVE-SENSITIZATION, SUBTHALAMIC NUCLEUS, PERSONALITY-FACTORS, SEEKING BEHAVIOR, DORSAL STRIATUM
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/153658
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