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Clinical implications of the global multidrug-resistant tuberculosis epidemic

Kumar, K; Abubakar, I; (2016) Clinical implications of the global multidrug-resistant tuberculosis epidemic. Clinical Medicine , 16 (6) pp. 565-570. 10.7861/clinmedicine.16-6-565. Green open access

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Abstract

Multidrug-resistant tuberculosis (MDR TB) is a significant threat to global health estimated to account for nearly half a million new cases and over 200,000 deaths in 2013. The number of MDR TB cases in the UK has risen over the last 15 years, with ever more complex clinical cases and associated challenging public health and societal implications. In this review, we provide an overview of the epidemiology of MDR TB globally and in the UK, outline the clinical management of MDR TB and summarise recent advances in diagnostics and prospects for new treatment.

Type: Article
Title: Clinical implications of the global multidrug-resistant tuberculosis epidemic
Open access status: An open access version is available from UCL Discovery
DOI: 10.7861/clinmedicine.16-6-565
Publisher version: http://dx.doi.org/10.7861/clinmedicine.16-6-565
Additional information: © Royal College of Physicians 2016. All rights reserved.
Keywords: Multidrug-resistant tuberculosis, epidemiology, diagnostics, treatment, Line Probe Assay, Mycobacterium-tuberculosis, Rifampicin Resistance, Xpert Mtb/rif, Pulmonary Tuberculosis, Rapid Detection, Delamanid, Impact, Metaanalysis
UCL classification: UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1536521
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