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The Neural Representation of Prospective Choice during Spatial Planning and Decisions

Kaplan, R; King, J; Koster, R; Penny, WD; Burgess, N; Friston, KJ; (2017) The Neural Representation of Prospective Choice during Spatial Planning and Decisions. PLOS BIOLOGY , 15 (1) , Article e1002588. 10.1371/journal.pbio.1002588. Green open access

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Abstract

We are remarkably adept at inferring the consequences of our actions, yet the neuronal mechanisms that allow us to plan a sequence of novel choices remain unclear. We used functional magnetic resonance imaging (fMRI) to investigate how the human brain plans the shortest path to a goal in novel mazes with one (shallow maze) or two (deep maze) choice points. We observed two distinct anterior prefrontal responses to demanding choices at the second choice point: one in rostrodorsal medial prefrontal cortex (rd-mPFC)/superior frontal gyrus (SFG) that was also sensitive to (deactivated by) demanding initial choices and another in lateral frontopolar cortex (lFPC), which was only engaged by demanding choices at the second choice point. Furthermore, we identified hippocampal responses during planning that correlated with subsequent choice accuracy and response time, particularly in mazes affording sequential choices. Psychophysiological interaction (PPI) analyses showed that coupling between the hippocampus and rd-mPFC increases during sequential (deep versus shallow) planning and is higher before correct versus incorrect choices. In short, using a naturalistic spatial planning paradigm, we reveal how the human brain represents sequential choices during planning without extensive training. Our data highlight a network centred on the cortical midline and hippocampus that allows us to make prospective choices while maintaining initial choices during planning in novel environments.

Type: Article
Title: The Neural Representation of Prospective Choice during Spatial Planning and Decisions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pbio.1002588
Publisher version: http://dx.doi.org/10.1371/journal.pbio.1002588
Language: English
Additional information: © 2017 Kaplan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Biology, Life Sciences & Biomedicine - Other Topics, MEDIAL PREFRONTAL CORTEX, ANTERIOR CINGULATE CORTEX, HUMAN ORBITOFRONTAL CORTEX, DEFAULT MODE, SUCCESSOR REPRESENTATION, FRONTOPOLAR CORTEX, LEARNING-SYSTEMS, SUBJECTIVE VALUE, MEMORY DEFICITS, HIPPOCAMPUS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1536028
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