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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Horikoshi, M; Yaghootkar, H; Mook-Kanamori, DO; Sovio, U; Taal, HR; Hennig, BJ; Bradfield, JP; ... Zhang, H; + view all (2013) New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics , 45 (1) pp. 76-82. 10.1038/ng.2477.

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Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.

Type: Article
Title: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
DOI: 10.1038/ng.2477
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1535640
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