Verfaillie, SC;
Tijms, B;
Versteeg, A;
Benedictus, MR;
Bouwman, FH;
Scheltens, P;
Barkhof, F;
... van der Flier, WM; + view all
(2016)
Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 5
pp. 43-52.
10.1016/j.dadm.2016.10.007.
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Abstract
INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD). METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia. RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI. DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.
| Type: | Article |
|---|---|
| Title: | Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.dadm.2016.10.007 |
| Publisher version: | http://doi.org/10.1016/j.dadm.2016.10.007 |
| Language: | English |
| Additional information: | © 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Alzheimer's disease cortical signature, Cognitive complaint, Cognitively normal, Cortical thickness, Dementia, MCI, MRI, Subjective cognitive decline |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1535636 |
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