Freeman, JA and Thompson, AJ and Fitzpatrick, R and Hutchinson, M and Miltenburger, C and Beckmann, K and Dahlke, F and Kappos, L and Polman, C and Pozzilli, C and European Study Grp Interferon-Beta1b, (2001) Interferon-beta 1b in the treatment of secondary progressive MS - Impact on quality of life. NEUROLOGY , 57 (10) 1870 - 1875.
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Background: The recent randomized, controlled trial of interferon-beta 1b (IFN-beta 1b) in 718 patients with secondary progressive MS (SP-MS) demonstrated a significant effect on the development of disability as evaluated by the physician. Its effect on patient-reported health-related quality of life (HrQoL) is reported herein. Methods: In this multicenter, double-blind, randomized, placebo-controlled trial, outpatients with SP-MS scoring between 3.0 and 6.5 on the Expanded Disability Status Scale received either 8 x 10(6) IU of IFN-beta 1b or placebo for up to 3 years. A range of outcomes was measured, including HrQoL, which was assessed using the Sickness Impact Profile (SIP), a self-report questionnaire validated for use in MS. Measurements were undertaken at baseline and at 6-monthly intervals thereafter for 36 months. Results: A slight positive effect on the HrQoL of the IFN group in comparison with the placebo group was found, which reached significance in the physical scale of the SIP at 6 and 12 months and at last visit. There was moderate correlation between physician-assessed evaluation of change and patient-reported change. Conclusions: IFN-beta 1b may delay sustained deterioration in patient-reported HrQoL in SP-MS. Methods of interpreting change in HrQoL are currently insufficiently developed to determine how clinically important these changes are for this population.
|Title:||Interferon-beta 1b in the treatment of secondary progressive MS - Impact on quality of life|
|Keywords:||MULTIPLE-SCLEROSIS PATIENTS, BETA-1B, PROFILE, TRIAL, REHABILITATION, VALIDATION, DISABILITY, PEOPLE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences|
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