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Hippocampal damage and memory impairment in congenital cyanotic heart disease

Munoz-Lopez, M; Hoskote, A; Chadwick, MJ; Dzieciol, AM; Gadian, DG; Chong, K; Banks, T; ... Vargha-Khadem, F; + view all (2017) Hippocampal damage and memory impairment in congenital cyanotic heart disease. HIPPOCAMPUS , 27 (4) pp. 417-424. 10.1002/hipo.22700. Green open access

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Abstract

Neonatal hypoxia can lead to hippocampal atrophy, which can lead, in turn, to memory impairment. To test the generalizability of this causal sequence, we examined a cohort of 41 children aged 8-16, who, having received the arterial switch operation to correct for transposition of the great arteries, had sustained significant neonatal cyanosis but were otherwise neurodevelopmentally normal. As predicted, the cohort had significant bilateral reduction of hippocampal volumes relative to the volumes of 64 normal controls. They also had significant, yet selective, impairment of episodic memory as measured by standard tests of memory, despite relatively normal levels of intelligence, academic attainment, and verbal fluency. Across the cohort, degree of memory impairment was correlated with degree of hippocampal atrophy suggesting that even as early as neonatal life no other structure can fully compensate for hippocampal injury and its special role in serving episodic long term memory.

Type: Article
Title: Hippocampal damage and memory impairment in congenital cyanotic heart disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hipo.22700
Additional information: © 2017 The Authors. Hippocampus Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, congenital heart disease, transposition of the great arteries, perinatal hypoxia-ischaemia, memory, hippocampus, HYPOTHERMIC CIRCULATORY ARREST, FLOW CARDIOPULMONARY BYPASS, ARTERIAL SWITCH OPERATION, HYPOXIC-ISCHEMIC-INJURY, GREAT-ARTERIES, DEVELOPMENTAL AMNESIA, CHILDREN, TRANSPOSITION, INFANTS, SURGERY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1535175
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