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Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study.

Holmberg, L; Wong, YNS; Tabár, L; Ringberg, A; Karlsson, P; Arnesson, L-G; Sandelin, K; ... Emdin, S; + view all (2013) Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study. Br J Cancer , 108 (4) pp. 812-819. 10.1038/bjc.2013.26.

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Abstract

BACKGROUND: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. METHODS: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. RESULTS: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease. The relative risk (RR) of a new IBE comparing those with casting-type calcifications to those without calcifications was 2.10 (95% confidence interval (CI) 0.92-4.80). This risk was confined to in situ recurrences; the RR of an IBE associated with casting-type calcifications on the mammogram adjusted for age and disease extent was 16.4 (95% CI 2.20-140). CONCLUSION: Mammographic appearance of ductal carcinoma in situ of the breast is prognostic for the risk of an in situ IBE and may also be an indicator of responsiveness to RT in younger women.

Type: Article
Title: Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study.
Location: England
DOI: 10.1038/bjc.2013.26
Keywords: Aged, Breast Neoplasms, Calcinosis, Carcinoma, Intraductal, Noninfiltrating, Cohort Studies, Female, Humans, Mammography, Middle Aged, Necrosis, Neoplasm Metastasis, Prognosis, Recurrence, Risk Assessment
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1533971
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