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Combining gene and stem cell therapy for peripheral nerve tissue engineering

Busuttil, F; Rahim, AA; Phillips, JB; (2017) Combining gene and stem cell therapy for peripheral nerve tissue engineering. Stem Cells and Development , 26 (4) pp. 231-238. 10.1089/scd.2016.0188. Green open access

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Abstract

Despite a substantially increased understanding of neuropathophysiology, insufficient functional recovery after peripheral nerve injury (PNI) remains a significant clinical challenge. Nerve regeneration following injury is dependent on Schwann cells, the supporting cells in the peripheral nervous system. Following nerve injury, Schwann cells adopt a pro-regenerative phenotype which supports and guides regenerating nerves. However, this phenotype may not persist long enough to ensure functional recovery. Tissue engineered nerve repair devices containing therapeutic cells that maintain the appropriate phenotype may help enhance nerve regeneration. The combination of gene and cell therapy is an emerging experimental strategy which seeks to provide the optimal environment for axonal regeneration and re-establishment of functional circuits. This review aims to summarise current pre-clinical evidence with potential for future translation from bench to bedside.

Type: Article
Title: Combining gene and stem cell therapy for peripheral nerve tissue engineering
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1089/scd.2016.0188
Publisher version: http://dx.doi.org/10.1089/scd.2016.0188
Language: English
Additional information: Copyright © Mary Ann Liebert, Inc. The final publication is available from Mary Ann Liebert, Inc. publishers at http://dx.doi.org/10.1089/scd.2016.0188
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1533036
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