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Cyanobacteria as Chassis for Industrial Biotechnology: Progress and Prospects

Al-Haj, L; Lui, YT; Abed, RM; Gomaa, MA; Purton, S; (2016) Cyanobacteria as Chassis for Industrial Biotechnology: Progress and Prospects. Life , 6 (4) , Article 42. 10.3390/life6040042. Green open access

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Abstract

Cyanobacteria hold significant potential as industrial biotechnology (IB) platforms for the production of a wide variety of bio-products ranging from biofuels such as hydrogen, alcohols and isoprenoids, to high-value bioactive and recombinant proteins. Underpinning this technology, are the recent advances in cyanobacterial "omics" research, the development of improved genetic engineering tools for key species, and the emerging field of cyanobacterial synthetic biology. These approaches enabled the development of elaborate metabolic engineering programs aimed at creating designer strains tailored for different IB applications. In this review, we provide an overview of the current status of the fields of cyanobacterial omics and genetic engineering with specific focus on the current molecular tools and technologies that have been developed in the past five years. The paper concludes by giving insights on future commercial applications of cyanobacteria and highlights the challenges that need to be addressed in order to make cyanobacterial industrial biotechnology more feasible in the near future.

Type: Article
Title: Cyanobacteria as Chassis for Industrial Biotechnology: Progress and Prospects
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/life6040042
Publisher version: http://dx.doi.org/10.3390/life6040042
Additional information: © 1996-2016 MDPI AG (Basel, Switzerland). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Keywords: bio-products, biofuels, biotechnology, cyanobacteria, genetic engineering
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1532751
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