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InterPro in 2017-beyond protein family and domain annotations

Finn, RD; Attwood, TK; Babbitt, PC; Bateman, A; Bork, P; Bridge, AJ; Chang, HY; ... Mitchell, AL; + view all (2016) InterPro in 2017-beyond protein family and domain annotations. Nucleic Acids Research 10.1093/nar/gkw1107. (In press). Green open access

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Abstract

InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.

Type: Article
Title: InterPro in 2017-beyond protein family and domain annotations
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/nar/gkw1107
Publisher version: http://dx.doi.org/10.1093/nar/gkw1107
Additional information: © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1532730
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