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COMPLETE ASSIGNMENT OF THE H-1 AND C-13 NMR-SPECTRA AND SOLUTION CONFORMATION OF THE ANTITUMOR ANTIBIOTIC, ACLACINOMYCIN-A

PARKINSON, JA; SADLER, IH; PICKUP, MB; TABOR, AB; (1995) COMPLETE ASSIGNMENT OF THE H-1 AND C-13 NMR-SPECTRA AND SOLUTION CONFORMATION OF THE ANTITUMOR ANTIBIOTIC, ACLACINOMYCIN-A. TETRAHEDRON , 51 (26) 7215 - 7222.

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Abstract

As a prelude to the study of the molecular recognition of DNA by anthracycline antibiotics, and as a basis for comparison with synthetic analogues the proton and carbon-13 NMR spectra of Aclacinomycin A in chloroform have been fully assigned and the likely solution conformation determined using COSY, HMQC and 1-D TOCSY and 1-D ROESY techniques. The D-ring of the fused tetracyclic ring system adopts a half-chair conformation and the sugar residues are shown to lie essentially in chair conformations with the glycosidic links diaxial. This imposes considerable restriction in the rotation about the glycosidic links.

Type: Article
Title: COMPLETE ASSIGNMENT OF THE H-1 AND C-13 NMR-SPECTRA AND SOLUTION CONFORMATION OF THE ANTITUMOR ANTIBIOTIC, ACLACINOMYCIN-A
Keywords: DNA, PULSES
UCL classification: UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/153271
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