HOLMES, AB and TABOR, AB and BAKER, R (1991) ENANTIOSELECTIVE SYNTHESIS OF (S)-TRANS-GAMMA-BUTENYNYL GAMMA-AMINOBUTYRIC-ACID (GABA). J CHEM SOC PERK T 1 (12) 3307 - 3313.
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The enantioselective synthesis of (S)-trans-gamma-butenynyl gamma-aminobutyric acid (GABA) 1 by phthalimide displacement of the (R)-alcohol 9 (generated from the acetal 3) is reported. Novel hydride reductions of the pentadiynylic ether 3 to the trans-enyne 5 are reported and discussed.
|Title:||ENANTIOSELECTIVE SYNTHESIS OF (S)-TRANS-GAMMA-BUTENYNYL GAMMA-AMINOBUTYRIC-ACID (GABA)|
|Keywords:||ORGANOMETALLIC COMPOUNDS, REDUCTIVE ALKYLATION, STEREOCHEMISTRY, HYDRALUMINATION, DERIVATIVES, ACETYLENES, ALCOHOLS, CIS|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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