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The sacral autonomic outflow is sympathetic

Espinosa-Medina, I; Saha, O; Boismoreau, F; Chettouh, Z; Rossi, F; Richardson, WD; Brunet, J-F; (2016) The sacral autonomic outflow is sympathetic. Science , 354 (6314) pp. 893-897. 10.1126/science.aah5454. Green open access

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Abstract

A kinship between cranial and pelvic visceral nerves of vertebrates has been accepted for a century. Accordingly, sacral preganglionic neurons are considered parasympathetic, as are their targets in the pelvic ganglia that prominently control rectal, bladder, and genital functions. Here, we uncover 15 phenotypic and ontogenetic features that distinguish pre- and postganglionic neurons of the cranial parasympathetic outflow from those of the thoracolumbar sympathetic outflow in mice. By every single one, the sacral outflow is indistinguishable from the thoracolumbar outflow. Thus, the parasympathetic nervous system receives input from cranial nerves exclusively and the sympathetic nervous system from spinal nerves, thoracic to sacral inclusively. This simplified, bipartite architecture offers a new framework to understand pelvic neurophysiology as well as development and evolution of the autonomic nervous system.

Type: Article
Title: The sacral autonomic outflow is sympathetic
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aah5454
Publisher version: http://doi.org/10.1126/science.aah5454
Language: English
Additional information: Copyright © 2016 American Association for the Advancement of Science. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science journal VOL 354 (6314), 18 Nov 2016, DOI: 10.1126/science.aah5454.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, HOMEOBOX GENE PHOX2B, RAT SPINAL-CORD, PREGANGLIONIC NEURONS, PARASYMPATHETIC NEURONS, TRANSCRIPTION FACTORS, INNERVATION, GANGLIA, DIFFERENTIATION, SPECIFICATION, MIGRATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/1530734
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