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The Classification of Protein Domains.

Dawson, N; Sillitoe, I; Marsden, RL; Orengo, CA; (2017) The Classification of Protein Domains. In: UNSPECIFIED (pp. 137-164).

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Abstract

The significant expansion in protein sequence and structure data that we are now witnessing brings with it a pressing need to bring order to the protein world. Such order enables us to gain insights into the evolution of proteins, their function and the extent to which the functional repertoire can vary across the three kingdoms of life. This has lead to the creation of a wide range of protein family classifications that aim to group proteins based upon their evolutionary relationships.In this chapter we discuss the approaches and methods that are frequently used in the classification of proteins, with a specific emphasis on the classification of protein domains. The construction of both domain sequence and domain structure databases is considered and we show how the use of domain family annotations to assign structural and functional information is enhancing our understanding of genomes.

Type: Book chapter
Title: The Classification of Protein Domains.
DOI: 10.1007/978-1-4939-6622-6_7
Keywords: Annotation, Classification, Clustering, Protein domain, Sequence, Structure, Amino Acid Sequence, Cluster Analysis, Databases, Protein, Protein Domains, Protein Structure, Tertiary, Proteins
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1530716
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