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Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans.

Tan, H; Pogosyan, A; Ashkan, K; Green, AL; Aziz, T; Foltynie, T; Limousin, P; ... Brown, P; + view all (2016) Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans. Elife , 5 , Article e19089. 10.7554/eLife.19089. Green open access

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Abstract

The basal ganglia are known to be involved in the planning, execution and control of gripping force and movement vigour. Here we aim to define the nature of the basal ganglia control signal for force and to decode gripping force based on local field potential (LFP) activities recorded from the subthalamic nucleus (STN) in patients with deep brain stimulation (DBS) electrodes. We found that STN LFP activities in the gamma (55-90 Hz) and beta (13-30 Hz) bands were most informative about gripping force, and that a first order dynamic linear model with these STN LFP features as inputs can be used to decode the temporal profile of gripping force. Our results enhance the understanding of how the basal ganglia control gripping force, and also suggest that deep brain LFPs could potentially be used to decode movement parameters related to force and movement vigour for the development of advanced human-machine interfaces.

Type: Article
Title: Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.19089
Publisher version: http://dx.doi.org/10.7554/eLife.19089
Language: English
Additional information: © Copyright Tan et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: Neuroscience, basal ganglia, beta oscillation, gamma oscillation, gripping force, Human, local field potentials
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1530712
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