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Semaphorin3A-neuropilin1 signalling is involved in the generation of cortical interneurons

Andrews, WD; Barber, M; Nemitz, M; Memi, F; Parnavelas, JG; (2017) Semaphorin3A-neuropilin1 signalling is involved in the generation of cortical interneurons. Brain Structure and Function , 222 (5) pp. 2217-2233. 10.1007/s00429-016-1337-3. Green open access

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Abstract

Cortical interneurons are generated predominantly in the medial ganglionic eminence of the ventral telencephalon and migrate to the cortex during embryonic development. These cells express neuropilin (Nrp1 and Nrp2) receptors which mediate their response to the chemorepulsive class 3 semaphorin (Sema) ligands. We show here that semaphorins Sema3A and Sema3F are expressed in layers adjacent to cortical interneuron migratory streams as well as in the striatum, suggesting they may have a role in guiding these cells throughout their journey. Analysis of Sema3A (-/-) and Sema3F (-/-) mice during corticogenesis showed that absence of Sema3A, but not Sema3F, leads to aberrant migration of cortical interneurons through the striatum. Reduced number of cortical interneurons was found in the cortex of Sema3A (-/-), Nrp1 (-/-) and Nrp2 (-/-) mice, as well as altered distribution in Sema3F (-/-), Nrp1 (-/-), Nrp2 (-/-) animals and especially in neuropilin double mutants. The observed decrease in interneurons in Sema3A (-/-) and Nrp1 (-/-) mice was due to altered proliferative activity of their progenitors highlighted by changes in their mitotic spindle positioning and angle of cleavage plane during cell division. These findings point to a novel role for Sema3A-Nrp1 signalling in progenitor cell dynamics and in the generation of interneurons in the ventral telencephalon.

Type: Article
Title: Semaphorin3A-neuropilin1 signalling is involved in the generation of cortical interneurons
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00429-016-1337-3
Publisher version: http://doi.org/10.1007/s00429-016-1337-3
Language: English
Additional information: Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creative commons.org/licenses/by/4.0/ ), which permits unrestricted use, distri- bution, andreproduction in anymedium, provided yougive appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Interneurons, Neuronal migration, Neuropilin, Proliferation, Semaphorin
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1530181
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