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Olaparib treatment for BRCA-mutant ovarian cancer with leptomeningeal disease

Bangham, M; Goldstein, R; Walton, H; Ledermann, JA; (2016) Olaparib treatment for BRCA-mutant ovarian cancer with leptomeningeal disease. Gynecologic Oncology Reports , 18 pp. 22-24. 10.1016/j.gore.2016.10.004. Green open access

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Abstract

HIGHLIGHTS: Leptomeningeal disease occurs more commonly in BRCA-mutated ovarian cancer; A clinically significant dose of olaprib is able to penetrate the leptomeninges; Leptomeningeal metastases in a BRCA-mutated ovarian cancer responded to olaparib.

Type: Article
Title: Olaparib treatment for BRCA-mutant ovarian cancer with leptomeningeal disease
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.gore.2016.10.004
Publisher version: https://doi.org/10.1016/j.gore.2016.10.004
Language: English
Additional information: Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Ovarian cancer; Brain metastases; Leptomeningeal disease; PARP inhibitor; Olaparib; BRCA mutation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre
URI: http://discovery.ucl.ac.uk/id/eprint/1529618
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