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Antibody arrays identify protein-protein interactions in chronic myeloid leukaemia.

Patel, H; Nteliopoulos, G; Nikolakopoulou, Z; Jackson, A; Gordon, MY; (2011) Antibody arrays identify protein-protein interactions in chronic myeloid leukaemia. Br J Haematol , 152 (5) pp. 611-614. 10.1111/j.1365-2141.2010.08450.x.

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Abstract

Multiprotein complex formation with p210(BCR-ABL1) is likely to play a major role in determining cellular abnormalities in chronic myeloid leukaemia (CML). Although many p210(BCR-ABL1) binding partners have been identified, it is likely that many have not. We evaluated the use of co-immunoprecipitation and antibody arrays and found that this approach is capable of identifying new p210(BCR-ABL1) binding partners, and may contribute to the search for new therapeutic targets in CML.

Type: Article
Title: Antibody arrays identify protein-protein interactions in chronic myeloid leukaemia.
Location: England
DOI: 10.1111/j.1365-2141.2010.08450.x
Keywords: Antibodies, Fusion Proteins, bcr-abl, Gene Expression Profiling, Humans, Immunoprecipitation, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Neoplasm Proteins, Protein Array Analysis, Protein Binding, Protein Interaction Mapping, Tumor Cells, Cultured
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1529559
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