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Hippocampal and diencephalic pathology in developmental amnesia.

Dzieciol, AM; Bachevalier, J; Saleem, KS; Gadian, DG; Saunders, R; Chong, WK; Banks, T; ... Vargha-Khadem, F; + view all (2017) Hippocampal and diencephalic pathology in developmental amnesia. Cortex , 86 pp. 33-44. 10.1016/j.cortex.2016.09.016. Green open access

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Abstract

Developmental amnesia (DA) is a selective episodic memory disorder associated with hypoxia-induced bilateral hippocampal atrophy of early onset. Despite the systemic impact of hypoxia-ischaemia, the resulting brain damage was previously reported to be largely limited to the hippocampus. However, the thalamus and the mammillary bodies are parts of the hippocampal-diencephalic network and are therefore also at risk of injury following hypoxic-ischaemic events. Here, we report a neuroimaging investigation of diencephalic damage in a group of 18 patients with DA (age range 11-35 years), and an equal number of controls. Importantly, we uncovered a marked degree of atrophy in the mammillary bodies in two thirds of our patients. In addition, as a group, patients had mildly reduced thalamic volumes. The size of the anterior-mid thalamic (AMT) segment was correlated with patients' visual memory performance. Thus, in addition to the hippocampus, the diencephalic structures also appear to play a role in the patients' memory deficit.

Type: Article
Title: Hippocampal and diencephalic pathology in developmental amnesia.
Location: Italy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cortex.2016.09.016
Publisher version: http://dx.doi.org/10.1016/j.cortex.2016.09.016
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Hippocampus, Hypoxia-ischaemia, Mammillary bodies, Memory, Thalamus
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1529542
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