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Admixture in Latin America

Adhikari, K; Mendoza-Revilla, J; Chacón-Duque, JC; Fuentes-Guajardo, M; Ruiz-Linares, A; (2016) Admixture in Latin America. [Review]. Current Opinion in Genetics & Development , 41 pp. 106-114. 10.1016/j.gde.2016.09.003. Green open access

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Abstract

Latin Americans arguably represent the largest recently admixed populations in the world. This reflects a history of massive settlement by immigrants (mostly Europeans and Africans) and their variable admixture with Natives, starting in 1492. This process resulted in the population of Latin America showing an extensive genetic and phenotypic diversity. Here we review how genetic analyses are being applied to examine the demographic history of this population, including patterns of mating, population structure and ancestry. The admixture history of Latin America, and the resulting extensive diversity of the region, represents a natural experiment offering an advantageous setting for genetic association studies. We review how recent analyses in Latin Americans are contributing to elucidating the genetic architecture of human complex traits.

Type: Article
Title: Admixture in Latin America
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.gde.2016.09.003
Publisher version: http://dx.doi.org/10.1016/j.gde.2016.09.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1528979
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