UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Biomimetic Hybrid Nanocontainers with Selective Permeability

Messager, L; Burns, JR; Kim, J; Cecchin, D; Hindley, J; Pyne, ALB; Gaitzsch, J; ... Howorka, S; + view all (2016) Biomimetic Hybrid Nanocontainers with Selective Permeability. Angewandte Chemie - International Edition , 55 (37) pp. 11106-11109. 10.1002/anie.201604677. Green open access

[img]
Preview
Text
Messager Biomimetic Hybrid Nanocontainers with Selective Permeability Angewandte Chemie International ed.pdf - ["content_typename_Published version" not defined]

Download (2MB) | Preview

Abstract

Chemistry plays a crucial role in creating synthetic analogues of biomacromolecular structures. Of particular scientific and technological interest are biomimetic vesicles that are inspired by natural membrane compartments and organelles but avoid their drawbacks, such as membrane instability and limited control over cargo transport across the boundaries. In this study, completely synthetic vesicles were developed from stable polymeric walls and easy-to-engineer membrane DNA nanopores. The hybrid nanocontainers feature selective permeability and permit the transport of organic molecules of 1.5 nm size. Larger enzymes (ca. 5 nm) can be encapsulated and retained within the vesicles yet remain catalytically active. The hybrid structures constitute a new type of enzymatic nanoreactor. The high tunability of the polymeric vesicles and DNA pores will be key in tailoring the nanocontainers for applications in drug delivery, bioimaging, biocatalysis, and cell mimicry.

Type: Article
Title: Biomimetic Hybrid Nanocontainers with Selective Permeability
Location: Seville, SPAIN
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/anie.201604677
Publisher version: http://dx.doi.org/10.1002/anie.201604677
Language: English
Additional information: Copyright © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co KGaA. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: DNA; enzymes; membranes; nanopores; nanotechnology; polymersomes
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/1528760
Downloads since deposit
66Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item