Lees, AJ and Hardy, J and Revesz, T (2009) Parkinson's disease. LANCET , 373 (9680) 2055 - 2066.
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Parkinson's disease is a common progressive bradykinetic disorder that can be accurately diagnosed. It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation of aggregated alpha-synuclein in specific brain stem, spinal cord, and cortical regions. The main known risk factor is age. Susceptibility genes including a-synuclein, leucine rich repeat kinase 2 (LRRK-2), and glucocerebrosidase (GBA) have shown that genetic predisposition is another important causal factor. Dopamine replacement therapy considerably reduces motor handicap, and effective treatment of associated depression, pain, constipation, and nocturnal difficulties can improve quality of life. Embryonic stem cells and gene therapy are promising research therapeutic approaches.
|Keywords:||ALPHA-SYNUCLEIN PATHOLOGY, LEWY BODY DISEASE, DEEP-BRAIN-STIMULATION, PROGRESSIVE SUPRANUCLEAR PALSY, MULTIPLE SYSTEM ATROPHY, PHASE-I TRIAL, MITOCHONDRIAL DYSFUNCTION, SUBCUTANEOUS APOMORPHINE, PYRAMIDAL DEGENERATION, VASCULAR PARKINSONISM|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > RLW Institute of Neurological Sciences
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