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Second-trimester pregnancy loss is associated with activated C resistance.

Rai, R; Regan, L; Hadley, E; Dave, M; Cohen, H; (1996) Second-trimester pregnancy loss is associated with activated C resistance. Br J Haematol , 92 (2) pp. 489-490.

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Abstract

We have investigated whether activated protein C resistance (APCR) is associated with second-trimester miscarriage. The prevalence of APCR was significantly higher amongst women with a history of second-trimester miscarriage (10/50; 20%) compared with either women with a history of first-trimester miscarriages only (4/70; 5.7%) or a control group of parous women with no previous history of pregnancy losses (3/70; 4.3%) (P < 0.02). These results suggest that APCR may be an important mechanism of second-trimester pregnancy loss, possibly related to the increase in intravascular coagulation that occurs during pregnancy.

Type: Article
Title: Second-trimester pregnancy loss is associated with activated C resistance.
Location: England
Keywords: Abortion, Habitual, Adult, Female, Humans, Partial Thromboplastin Time, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Thrombosis
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1523334
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