Levytska, K;
Higgins, M;
Keating, S;
Melamed, N;
Walker, M;
Sebire, NJ;
Kingdom, JC;
(2017)
Placental Pathology in Relation to Uterine Artery Doppler Findings in Pregnancies with Severe Intrauterine Growth Restriction and Abnormal Umbilical Artery Doppler Changes.
American Journal of Perinatology
, 34
(5)
pp. 451-457.
10.1055/s-0036-1592347.
Preview |
Text
Sebire_Placental%20Pathology%20in%20Relation%20to%20Uterine%20Artery%20Doppler%20Findings%20in%20Pregnancies%20with%20Severe%20Intrauterine%20Growth%20Restriction.pdf - Accepted Version Download (299kB) | Preview |
Abstract
OBJECTIVES: Current guidelines for diagnosis and management of early-onset intrauterine growth restriction (IUGR) rely on umbilical artery Doppler (UAD), without including uterine artery Doppler (UtAD). We hypothesized that IUGR cases with abnormal UAD but normal UtAD has a different spectrum of placental pathology compared with those with abnormal UtAD. STUDY DESIGN: Retrospective review of pregnancies with sonographic evidence of IUGR and abnormal UAD prior to delivery. Cases with ≥ 1 UtAD record(s) after 18(+0) weeks' gestation and placental pathology were included. Cases were stratified according to initial UtAD pulsatility index (PI) values (n = 196): normal (n = 19; PI < 95th centile for gestational age/no notching), intermediate (n = 69; PI ≥ 95th centile/no/unilateral notching) and abnormal (n = 108; PI ≥ 95th centile/bilateral notching). Pregnancy outcomes and placental pathology were compared between groups. RESULTS: Women in the normal group delivered later than those in the abnormal group (30.1 ± 3.5 vs. 28.0 ± 3.5 weeks; mean ± standard deviation; p = 0.03). Their placentas exhibited higher rates of chronic intervillositis (15.8 vs. 0.9%; p = 0.01), chorangiosis (15.8 vs. 0.9%; p < 0.0001), and massive perivillous fibrin deposition (21.1 vs. 7.4%; p = 0.05), but had lower rates of uteroplacental vascular insufficiency (26.3 vs. 79.6%; p < 0.0001). CONCLUSION: Approximately 10% of pregnancies with early-onset IUGR and abnormal UAD exhibited normal UtAD waveforms. They delivered later, and their placentas exhibited unusual placental pathologies.
| Type: | Article |
|---|---|
| Title: | Placental Pathology in Relation to Uterine Artery Doppler Findings in Pregnancies with Severe Intrauterine Growth Restriction and Abnormal Umbilical Artery Doppler Changes |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1055/s-0036-1592347 |
| Publisher version: | http://dx.doi.org/10.1055/s-0036-1592347 |
| Language: | English |
| Additional information: | Copyright © by Thieme Medical Publishers, Inc. This is an Accepted Manuscript of an article published by Thieme Medical Publishers, Inc in Amer J Perinatol on [date of publication], available online: http://dx.doi.org/10.1055/s-0036-1592347 |
| Keywords: | Placental pathology, early-onset IUGR, uterine artery Doppler, umbilical artery Doppler |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1520254 |
Archive Staff Only
 |
View Item |
