UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk

Hulman, A; Simmons, RK; Vistisen, D; Tabák, AG; Dekker, JM; Alssema, M; Rutters, F; ... Færch, K; + view all (2017) Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk. Endocrine , 55 (2) pp. 427-434. 10.1007/s12020-016-1126-z. Green open access

[img]
Preview
Text
Tabak_GlucosePatterns_EndocrineRevised_clean.pdf

Download (394kB) | Preview

Abstract

We aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response curve groups. We analyzed data from 1,267 individuals without diabetes from five studies in Denmark, the Netherlands and the USA. Each study included between 5 and 11 measurements at different time points during a 2-h oral glucose tolerance test, resulting in 9,602 plasma glucose measurements. Latent class trajectories with a cubic specification for time were fitted to identify different patterns of plasma glucose change during the oral glucose tolerance test. Cardiometabolic risk factor profiles were compared between the identified groups. Using latent class trajectory analysis, five glucose response curves were identified. Despite similar fasting and 2-h values, glucose peaks and peak times varied greatly between groups, ranging from 7-12 mmol/L, and 35-70 min. The group with the lowest and earliest plasma glucose peak had the lowest estimated cardiovascular risk, while the group with the most delayed plasma glucose peak and the highest 2-h value had the highest estimated risk. One group, with normal fasting and 2-h values, exhibited an unusual profile, with the highest glucose peak and the highest proportion of smokers and men. The heterogeneity in glucose response curves and the distinct cardiometabolic risk profiles may reflect different underlying physiologies. Our results warrant more detailed studies to identify the source of the heterogeneity across the different phenotypes and whether these differences play a role in the development of type 2 diabetes and cardiovascular disease.

Type: Article
Title: Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s12020-016-1126-z
Publisher version: http://dx.doi.org/10.1007/s12020-016-1126-z
Language: English
Additional information: Copyright © Springer Science+Business Media New York 2016 The final publication is available at Springer via http://dx.doi.org/10.1007/s12020-016-1126-z
Keywords: Cardiometabolic risk, Glucose response curve, Latent class trajectory analysis, Oral glucose tolerance test
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/1520241
Downloads since deposit
100Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item