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Using imagination to understand the neural basis of episodic memory

Hassabis, D; Kumaran, D; Maguire, EA; (2007) Using imagination to understand the neural basis of episodic memory. J NEUROSCI , 27 (52) 14365 - 14374. 10.1523/JNEUROSCI.4549-07.2007. Gold open access

Abstract

Functional MRI (fMRI) studies investigating the neural basis of episodic memory recall, and the related task of thinking about plausible personal future events, have revealed a consistent network of associated brain regions. Surprisingly little, however, is understood about the contributions individual brain areas make to the overall recollective experience. To examine this, we used a novel fMRI paradigm in which subjects had to imagine fictitious experiences. In contrast to future thinking, this results in experiences that are not explicitly temporal in nature or as reliant on self-processing. By using previously imagined fictitious experiences as a comparison for episodic memories, we identified the neural basis of a key process engaged in common, namely scene construction, involving the generation, maintenance and visualization of complex spatial contexts. This was associated with activations in a distributed network, including hippocampus, parahippocampal gyrus, and retrosplenial cortex. Importantly, we disambiguated these common effects from episodic memory-specific responses in anterior medial prefrontal cortex, posterior cingulate cortex and precuneus. These latter regions may support self-schema and familiarity processes, and contribute to the brain's ability to distinguish real from imaginary memories. We conclude that scene construction constitutes a common process underlying episodic memory and imagination of fictitious experiences, and suggest it may partially account for the similar brain networks implicated in navigation, episodic future thinking, and the default mode. We suggest that additional brain regions are co-opted into this core network in a task-specific manner to support functions such as episodic memory that may have additional requirements.

Type:Article
Title:Using imagination to understand the neural basis of episodic memory
Open access status:An open access publication
DOI:10.1523/JNEUROSCI.4549-07.2007
Publisher version:http://ukpmc.ac.uk/abstract/MED/18160644
Keywords:fMRI, episodic memory, imagination, scene, construction, recollection, AUTOBIOGRAPHICAL MEMORY, COGNITIVE NEUROSCIENCE, CONSTRUCTIVE MEMORY, HUMAN HIPPOCAMPUS, SPATIAL MEMORY, FUTURE, BRAIN, CORTEX, SELF, RETRIEVAL
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neuroscience Unit

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