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Long-term synaptic plasticity in hippocampal interneurons

Kullmann, DM; Lamsa, KP; (2007) Long-term synaptic plasticity in hippocampal interneurons. NAT REV NEUROSCI , 8 (9) 687 - 699. 10.1038/nrn2207.

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Abstract

Rapid memory formation relies, at least in part, on long- term potentiation ( LTP) of excitatory synapses. Inhibitory interneurons of the hippocampus, which are essential for information processing, have recently been found to exhibit not one, but two forms of LTP. One form resembles LTP that occurs in pyramidal neurons, which depends on N- methyl- D-aspartate receptors and is triggered by coincident pre- and postsynaptic activity. The other depends on Ca2+ influx through glutamate receptors that preferentially open when the postsynaptic neuron is at rest. Here we review these contrasting forms of LTP and describe how they are mirrored by two forms of long- term depression. We further discuss how the remarkable plasticity of glutamatergic synapses on interneurons greatly enhances the computational capacity of the cortical microcircuit.

Type: Article
Title: Long-term synaptic plasticity in hippocampal interneurons
DOI: 10.1038/nrn2207
Keywords: AMPA RECEPTOR SUBUNITS, CA1 PYRAMIDAL CELLS, RAT HIPPOCAMPUS, INTRACELLULAR POLYAMINES, INHIBITORY INTERNEURONS, GLUTAMATE RECEPTORS, CA2+-PERMEABLE AMPA, DIFFERENTIAL EXPRESSION, FEEDFORWARD INHIBITION, INWARD RECTIFICATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: http://discovery.ucl.ac.uk/id/eprint/151849
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