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Physical Activity, Sedentary Behavior, and Inflammatory and Hemostatic Markers in Men.
Medicine & Science in Sports & Exercise
Parsons_00005768-900000000-97382.pdf - ["content_typename_Accepted version" not defined]
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PURPOSE: To determine whether higher levels of physical activity (PA) and less sedentary behavior (SB) are associated with less inflammation, indicated by inflammatory and hemostatic biomarkers, in older men. METHODS: Cross-sectional study of 1139 men, from the British Regional Heart Study, age 78 (5) (mean (SD) y and longitudinal analyses of 490 men with two PA measures 1 year apart. Single fasting venous blood samples were analyzed for several biomarkers. PA and SB were measured using Actigraph GT3X accelerometers. Total time, and time spent in bouts of moderate to vigorous physical activity (MVPA), light physical activity and SB were derived. Linear regression analyses were used to investigate associations. RESULTS: Cross-sectionally, higher total PA, daily steps, and MVPA were all associated with lower levels of interleukin 6 (IL-6), C-reactive protein (CRP), tissue plasminogen activator (tPA), von Willebrand factor (vWF), and D-Dimer, whilst higher levels of SB were associated with higher levels of IL-6, CRP and tPA. Each additional 10 minutes of MVPA was associated with a 3.2% lower IL-6 (95% CI -4.5, -1.8%), 5.6% lower CRP (95% CI -7.8, -3.3), 2.2% lower tPA (95% CI -3.0, -1.4), 1.2% lower vWF (95% CI -2.1, -0.3) and 1.8% lower D-dimer (95% CI -2.9, 0.7), and for CRP, vWF and D-dimer independently of SB. Associations between SB and IL-6 or tPA were independent of MVPA. Longer bouts of PA or SB were not more strongly associated with outcomes than shorter bouts. Longitudinal analyses were inconsistent with these findings, possibly due to power limitations. CONCLUSION: Although PA (particularly MVPA) was generally associated with inflammatory and hemostatic biomarkers, we found no evidence that longer bouts were more important than shorter bouts.
|Title:||Physical Activity, Sedentary Behavior, and Inflammatory and Hemostatic Markers in Men|
|Open access status:||An open access version is available from UCL Discovery|
|Additional information:||Copyright © 2016 the Author(s). Published by Wolters Kluwer Health on behalf of the American College of Sports Medicine. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Primary Care and Population Health
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