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The importance of modeling epileptic seizure dynamics as spatio-temporal patterns

Baier, G; Goodfellow, M; Taylor, PN; Wang, Y; Garry, DJ; (2012) The importance of modeling epileptic seizure dynamics as spatio-temporal patterns. Frontiers in Physiology , 3 10.3389/fphys.2012.00281. Green open access

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Abstract

The occurrence of seizures is the common feature across the spectrum of epileptic disorders. We describe how the use of mechanistic neural population models leads to novel insight into the dynamic mechanisms underlying two important types of epileptic seizures. We specifically stress the need for a spatio-temporal description of the rhythms to deal with the complexity of the pathophenotype. Adapted to functional and structural patient data, the macroscopic models may allow a patient-specific description of seizures and prediction of treatment outcome.

Type: Article
Title: The importance of modeling epileptic seizure dynamics as spatio-temporal patterns
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fphys.2012.00281
Publisher version: http://dx.doi.org/10.3389/fphys.2012.00281
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. Article under Creative commons licence 4.0 http://creativecommons.org/licenses/by/4.0/.
Keywords: Computational modeling, electroencephalogram (EEG), epilepsy, heterogeneity, spatio-temporal patterns
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1517873
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