UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Analgesic Drug Prescription Patterns On Five International Paediatric Wards

Botzenhardt, S; Rashed, AN; Wong, ICK; Tomlin, S; Neubert, A; (2016) Analgesic Drug Prescription Patterns On Five International Paediatric Wards. Pediatric Drugs , 18 (6) pp. 465-473. 10.1007/s40272-016-0198-9. Green open access

[img]
Preview
Text
Wong_Pediatric drugs 2016 ADVISE_Analgesic_Children_Revision_01_clean.pdf

Download (566kB) | Preview

Abstract

Aim: Analgesic and anti-inflammatory drugs are frequently prescribed in paediatrics. Prescribing and dosing patterns in hospitalised children are not well known. This study explores analgesic drug utilisation on five paediatric wards and discusses its findings in comparison with World Health Organization (WHO) guidelines. / Method: A sub-analysis of a prospective, multicentre, observational cohort study was undertaken. Prescription data of children aged up to ≤18 years were collected between October 2008 and December 2009 on paediatric general medical wards in five hospitals in Australia, Germany, the United Kingdom (UK), Hong Kong (HK) and Malaysia. Analgesic drug prescriptions were analysed for prescribing patterns in terms of dosing, frequency and route of administration. Dosing data were compared with local recommendations and WHO guidelines for children. / Results: In the study cohort, 56.8 % (726/1278) of paediatric patients received at least one analgesic drug prescription (1227 prescriptions). The median age of patients with analgesics was 2.2 years [interquartile range (IQR) 0.8–7.3], and the median number of prescriptions per patient was one (IQR 1–2). The most commonly prescribed drugs were oral paracetamol (45.9 %, 563/1227) and oral ibuprofen (19.9 %, 244/1227). Daily doses of paracetamol ranged from 30 mg/kg/day in Germany to 67–68 mg/kg/day in the UK and HK (p < 0.05). For ibuprofen, single doses ranged from 5–6 mg/kg in HK and the UK to 10 mg/kg in Germany and Australia (p < 0.001). Opioid use prevalence was statistically different between the centres and ranged from 0 to 17.6 % (p < 0.001). / Conclusion: This study provides a comprehensive overview of analgesic drug use of hospitalised children. Similar to primary care data, paracetamol is the most commonly used analgesic. As recommended by WHO guidelines, oral medication was favoured and opioids used in addition to paracetamol and ibuprofen. Overall drug utilisation was in line with local recommendations and WHO guidelines. Differences in use of paracetamol and ibuprofen among countries were seen, indicating that safety concerns are perceived differently. More large-scale safety studies are needed.

Type: Article
Title: Analgesic Drug Prescription Patterns On Five International Paediatric Wards
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40272-016-0198-9
Publisher version: http://dx.doi.org/10.1007/s40272-016-0198-9
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/10.1007/s40272-016-0198-9.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
URI: http://discovery.ucl.ac.uk/id/eprint/1516146
Downloads since deposit
191Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item