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99Tcm-labelled leucocyte imaging in active rheumatoid arthritis.

Al-Janabi, MA; Jones, AK; Solanki, K; Sobnack, R; Bomanji, J; Al-Nahhas, AA; Doyle, DV; ... Huskisson, EC; + view all (1988) 99Tcm-labelled leucocyte imaging in active rheumatoid arthritis. Nucl Med Commun , 9 (12) pp. 987-991.

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Abstract

A simplified technique of labelling leucocytes with technetium-99m is described and applied to patients with active rheumatoid arthritis. The clinically active and less active knees in seven patients were imaged and the uptake of labelled leucocytes was measured. The measurements were repeated after local steroid injection into nine painful knees. A 50-80% reduction in leucocyte uptake localized to the region of the synovium was demonstrated in the eight knees which showed clinical responses and a rise of 8% in the non-responder. There was a variable response in the knees that were not injected. 99Tcm leucocyte imaging in rheumatoid arthritis is able to assess objectively joint inflammation and its response to treatment.

Type: Article
Title: 99Tcm-labelled leucocyte imaging in active rheumatoid arthritis.
Location: England
Keywords: Aged, Arthritis, Rheumatoid, Female, Humans, Injections, Intra-Articular, Isotope Labeling, Knee Joint, Leukocytes, Male, Middle Aged, Organometallic Compounds, Oximes, Radionuclide Imaging, Technetium, Technetium Tc 99m Exametazime, Triamcinolone Acetonide
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1515316
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