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Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation

Bartlett, RD; Choi, D; Phillips, JB; (2016) Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation. Regenrative Medicine , 11 (7) pp. 659-673. 10.2217/rme-2016-0065. Green open access

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Abstract

Spinal cord injury is a severely debilitating condition which can leave individuals paralyzed and suffering from autonomic dysfunction. Regenerative medicine may offer a promising solution to this problem. Previous research has focused primarily on exploring the cellular and biological aspects of the spinal cord, yet relatively little remains known about the biomechanical properties of spinal cord tissue. Given that a number of regenerative strategies aim to deliver cells and materials in the form of tissue-engineered therapies, understanding the biomechanical properties of host spinal cord tissue is important. We review the relevant biomechanical properties of spinal cord tissue and provide the baseline knowledge required to apply these important physical concepts to spinal cord tissue engineering.

Type: Article
Title: Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/rme-2016-0065
Publisher version: http://dx.doi.org/10.2217/rme-2016-0065
Language: English
Additional information: This is the peer reviewed version of the following article: James B. Phillips, Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation, Regenerative Medicine October 2016 ,Vol. 11, No. 7, Pages 659-673, which has been published in final form at: 10.2217/rme-2016-0065
Keywords: Science & Technology, Life Sciences & Biomedicine, Technology, Cell & Tissue Engineering, Engineering, Biomedical, Cell Biology, Engineering, biomechanical properties, biomechanics, CNS, mechanical properties, regenerative medicine, spinal cord, spinal cord injury, spinal cord repair, tissue engineering, MAGNETIC-RESONANCE ELASTOGRAPHY, CENTRAL-NERVOUS-SYSTEM, TRAUMATIC BRAIN-INJURY, MECHANICAL-PROPERTIES, WHITE-MATTER, VISCOELASTIC PROPERTIES, IN-VIVO, BIOLOGICAL TISSUES, FORCE MICROSCOPY, MR ELASTOGRAPHY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1514941
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