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Molecular mechanisms of archaeal RNA polymerase

Grohmann, D; Hirtreiter, A; Werner, F; (2009) Molecular mechanisms of archaeal RNA polymerase. BIOCHEMICAL SOCIETY TRANSACTIONS , 37 12 - 17. 10.1042/BST0370012.

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Abstract

All cellular life depends on multisubunit RNAPs (RNA polymerases) that are evolutionarily related through the three domains of life. Archaeal RNAPs encompass 12 subunits that contribute in different ways to the assembly and stability of the enzyme, nucleic acid binding, catalysis and specific regulatory interactions with transcription factors. The recent development of methods to reconstitute archaeal RNAP from recombinant materials in conjunction with structural information of multisubunit RNAPs present a potent opportunity to investigate the molecular mechanisms of transcription.

Type: Article
Title: Molecular mechanisms of archaeal RNA polymerase
Location: Univ St Andrews, St Andrews, SCOTLAND
DOI: 10.1042/BST0370012
Keywords: archaeon, evolution, RNA polymerase, transcription, HYPERTHERMOPHILIC ARCHAEON, PREINITIATION COMPLEX, TRANSCRIPTION FACTORS, PROMOTER, SUBUNIT, TERMINATION, EVOLUTION, CLEAVAGE, EXPRESSION, SEQUENCES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/151442
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