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The prognostic influence of bcl-2 in malignant glioma

McDonald, FE; Ironside, JW; Gregor, A; Wyatt, B; Stewart, M; Rye, R; ... Potts, HWW; + view all (2002) The prognostic influence of bcl-2 in malignant glioma. BRIT J CANCER , 86 (12) 1899 - 1904. 10.1038/sj.bjc.6600217.

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Abstract

The bcl-2 gene is one of a complex group of genes which control programmed cell death, Bcl-2 acts to extend cell survival by blocking apoptosis, and thereby may influence tumour prognosis, This study of 187 high grade gliomas reviews clinicopathological prognostic features and the relationship to bcl-2 expression. Bcl-2 immunostaining was assessed in 159 specimens from these patients, by scoring systems of 0 to 3 for intensity of scoring and proportion of cells staining. Age, histology, pre- and post-operative performance status were found to be strongly predictive of survival (log rank test P<0.0001). The type of surgery performed did not influence survival in this group of patients. The expression of bcl-2 had a significant relationship with survival (univariate Cox model P=0.0302, hazard ratio 0.8, 95% confidence interval 0.65-0.98), with increased staining associated with improved survival. Multivariate analysis showed performance status, histology and proportion of cells staining for bcl-2 to be independently predictive of survival. Bcl-2 staining was not related to histological grade of tumours. (C) 2002 Cancer Research UK.

Type:Article
Title:The prognostic influence of bcl-2 in malignant glioma
DOI:10.1038/sj.bjc.6600217
Keywords:high grade glioma, bcl-2, multivariate analysis, PROTEIN EXPRESSION, CELL-DEATH, ASTROCYTIC TUMORS, GLIOBLASTOMA-MULTIFORME, PROTOONCOGENE BCL-2, PATIENT SURVIVAL, BREAST-CANCER, IN-VIVO, P53, FAMILY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > CHIME

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