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Treatment recommendations from the Eighth International Workshop on Waldenstrom's Macroglobulinemia

Leblond, V; Kastritis, E; Advani, R; Ansell, SM; Buske, C; Castillo, JJ; Garcia-Sanz, R; ... Dimopoulos, MA; + view all (2016) Treatment recommendations from the Eighth International Workshop on Waldenstrom's Macroglobulinemia. Blood , 128 (10) pp. 1321-1328. 10.1182/blood-2016-04-711234. Green open access

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Abstract

Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy have been proposed as part of the consensus panels of the International Workshop on Waldenström’s Macroglobulinemia (IWWM). At IWWM-8, a task force for treatment recommendations was impanelled to review recently published and ongoing clinical trial data as well as the impact of new mutations (MYD88 and CXCR4) on treatment decisions, indications for B-cell receptor and proteasome inhibitors, and future clinical trial initiatives for WM patients. The panel concluded that therapeutic strategies in WM should be based on individual patient and disease characteristics. Chemoimmunotherapy combinations with rituximab and cyclophosphamide-dexamethasone, bendamustine, or bortezomib-dexamethasone provide durable responses and are still indicated in most patients. Approval of the BTK inhibitor ibrutinib in the United States and Europe represents a novel and effective treatment option for both treatment-naive and relapsing patients. Other B-cell receptor inhibitors, second-generation proteasome inhibitors (eg, carfilzomib), and mammalian target of rapamycin inhibitors are promising and may increase future treatment options. Active enrollment in clinical trials whenever possible was endorsed by the panel for most patients with WM.

Type: Article
Title: Treatment recommendations from the Eighth International Workshop on Waldenstrom's Macroglobulinemia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1182/blood-2016-04-711234
Publisher version: http://dx.doi.org/10.1182/blood-2016-04-711234
Language: English
Additional information: Copyright © 2016 by The American Society of Hematology. This research was originally published in Blood. Leblond, V., Kastritis, E., Advani, R., Ansell, S. M., Buske, C., Castillo, J. J., García-Sanz, R., Gertz, M., Kimby, E., Kyriakou, C., Merlini, G., Minnema, M. C., Morel, P., Morra, E., Rummel, M., Wechalekar, A., Patterson, C. J., Treon, S. P., & Dimopoulos, M. A. (2016). Treatment recommendations from the Eighth International Workshop on Waldenström’s Macroglobulinemia. Blood, 128(10), 1321-1328. http://dx.doi.org/10.1182/blood-2016-04-711234. © the American Society of Hematology.
Keywords: Science & Technology, Life Sciences & Biomedicine, Hematology, Consensus Panel Recommendations, Phase-Ii Trial, Cooperative-Oncology-Group, Late-Onset Neutropenia, Von-Willebrand-Factor, Weekly Bortezomib, Waidenstroms Macroglobulinemia, Rituximab Treatment, Primary Therapy, Cyclophosphamide
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/1512519
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