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Human mitochondrial complex I dysfunction

Cooper, JM; Mann, VM; Krige, D; Schapira, AHV; (1992) Human mitochondrial complex I dysfunction. Biochimica et Biophysica Acta - Bioenergetics , 1101 (2) pp. 199-203. 10.1016/0005-2728(92)90224-P.

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Abstract

In humans, complex I dysfunction has been observed in a high percentage of patients with mitochondrial myopathy. Analysis of mitochondria from these patients suggests the function and assembly of complex I is particularly susceptible to abnormalities of mitochondrial DNA, involving either point mutations of tRNA genes or major deletions. The evidence for a complex I defect in Parkinson's disease is accumulating, although the cause of this deficiency or the role it plays in the events that culminate in dopaminergic cell death remains unresolved. © 1992, All rights reserved.

Type: Article
Title: Human mitochondrial complex I dysfunction
DOI: 10.1016/0005-2728(92)90224-P
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1511605
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