Eldholm, V;
Rieux, A;
Monteserin, J;
Lopez, JM;
Palmero, D;
Lopez, B;
Ritacco, V;
... Balloux, F; + view all
(2016)
Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis.
eLife
, 5
, Article e16644. 10.7554/eLife.16644.
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Abstract
The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.
| Type: | Article |
|---|---|
| Title: | Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.16644 |
| Publisher version: | https://doi.org/10.7554/eLife.16644 |
| Language: | English |
| Additional information: | Copyright © 2016, Eldholm et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. redistribution provided that the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1511558 |
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