Rigoli, F;
Friston, KJ;
Dolan, RJ;
(2016)
Neural processes mediating contextual influences on human choice behaviour.
Nature Communications
, 7
(12416)
10.1038/ncomms12416.
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Abstract
Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine functional magnetic resonance imaging (fMRI) data during performance of a gambling task where blocks comprise values drawn from one of two different, but partially overlapping, reward distributions or contexts. At the beginning of each block (when information about context is provided), hippocampus is activated and this response is enhanced when contextual influence on choice increases. In addition, response to value in ventral tegmental area/substantia nigra (VTA/SN) shows context-sensitivity, an effect enhanced with an increased contextual influence on choice. Finally, greater response in hippocampus at block start is associated with enhanced context sensitivity in VTA/SN. These findings suggest that context-sensitive choice is driven by a brain circuit involving hippocampus and dopaminergic midbrain.
| Type: | Article |
|---|---|
| Title: | Neural processes mediating contextual influences on human choice behaviour |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ncomms12416 |
| Publisher version: | http://dx.doi.org/10.1038/ncomms12416 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, GOAL-DIRECTED BEHAVIOR, DECISION-MAKING, ORBITOFRONTAL CORTEX, DISSOCIABLE ROLES, VENTRAL STRIATUM, SUBJECTIVE VALUE, DORSAL STRIATUM, GAIN-CONTROL, REWARD VALUE, PLACE CELLS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508796 |
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