Saracino, AM; Denton, CP; Orteu, CH; (2017) The molecular pathogenesis of morphoea: from genetics to future treatment targets. British Journal of Dermatology , 177 (1) pp. 34-46. 10.1111/bjd.15001.

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Abstract

A number of immunoinflammatory and profibrotic mechanisms are recognised in the pathogenesis of broad sclerotic skin processes, and more specifically, morphoea. However, precise aetiopathogenesis is complex and remains unclear. Morphoea is clinically heterogeneous, with variable anatomical patterning, depth of tissue involvement, and sclerotic, inflammatory, atrophic and dyspigmented morphology. Underlying mechanisms determining these reproducible clinical subsets are poorly understood, but of great clinical and therapeutic relevance. Regional susceptibility mechanisms (such as environmental triggers, mosaicism and positional identity) together with distinct pathogenic determinants (including innate, adaptive and imbalanced pro and anti-fibrotic signaling pathways) are likely implicated. In the age of genetic profiling and personalised medicine, improved characterisation of the environmental, systemic, local, genetic and immunopathologic factors underpinning morphoea pathogenesis, may open the door to novel targeted therapeutic approaches. This article is protected by copyright. All rights reserved.

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